Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

The kinetochore is responsible for accurate chromosome segregation. However, the mechanism by which kinetochores assemble and are maintained remains unclear. Here we report that de novo CENP-A assembly and kinetochore formation on human centromeric alphoid DNA arrays is regulated by a histone H3K9 a...

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Autors principals: Ohzeki, Jun-ichirou, Bergmann, Jan H, Kouprina, Natalay, Noskov, Vladimir N, Nakano, Megumi, Kimura, Hiroshi, Earnshaw, William C, Larionov, Vladimir, Masumoto, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364751/
https://ncbi.nlm.nih.gov/pubmed/22473132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.82
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