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Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly
The kinetochore is responsible for accurate chromosome segregation. However, the mechanism by which kinetochores assemble and are maintained remains unclear. Here we report that de novo CENP-A assembly and kinetochore formation on human centromeric alphoid DNA arrays is regulated by a histone H3K9 a...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364751/ https://ncbi.nlm.nih.gov/pubmed/22473132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.82 |
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