Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators

The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, and calcium homeostasis. The receptor is activated by vitamin D analogs that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interactions. The interactions...

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Huvudupphovsmän: Nandhikonda, Premchendar, Lynt, Wen Z., McCallum, Megan M., Ara, Tahniyath, Baranowski, Athena M., Yuan, Nina Y., Pearson, Dana, Bikle, Daniel D., Guy, R. Kiplin, Arnold, Leggy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364162/
https://ncbi.nlm.nih.gov/pubmed/22563729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300460c
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