Thermodynamics and Docking of Agonists to the β(2)-Adrenoceptor Determined Using [(3)H](R,R′)-4-Methoxyfenoterol as the Marker Ligand

G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intracellular components. The detailed interaction of a molecule with a G protein-coupled receptor is a com...

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Bibliografiske detaljer
Main Authors: Toll, Lawrence, Pajak, Karolina, Plazinska, Anita, Jozwiak, Krzysztof, Jimenez, Lucita, Kozocas, Joseph A., Tanga, Mary J., Bupp, James E., Wainer, Irving W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2012
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362895/
https://ncbi.nlm.nih.gov/pubmed/22434858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.077347
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