Sulfation of 4-Hydroxy Toremifene: Individual Variability, Isoform Specificity, and Contribution to Toremifene Pharmacogenomics

Toremifene (TOR) is a selective estrogen receptor modulator used in adjuvant therapy for breast cancer and in clinical trials for prostate cancer prevention. The chemical structure of TOR differs from that of tamoxifen (TAM) by the presence of a chlorine atom in the ethyl side chain, resulting in a...

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Bibliographic Details
Main Authors: Edavana, Vineetha Koroth, Dhakal, Ishwori B., Yu, Xinfeng, Williams, Suzanne, Kadlubar, Susan
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362788/
https://ncbi.nlm.nih.gov/pubmed/22434874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.044040
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