Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics

Anastrozole belongs to the nonsteroidal triazole-derivative group of aromatase inhibitors. Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity with third-generation aromatase inhibitors, compared with tamoxifen. Anastrozole is predominantly metabolized by ph...

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Bibliographic Details
Main Authors: Edavana, Vineetha Koroth, Dhakal, Ishwori B., Williams, Suzanne, Penney, Rosalind, Boysen, Gunnar, Yao-Borengasser, Aiwei, Kadlubar, Susan
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608453/
https://ncbi.nlm.nih.gov/pubmed/23371966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048157
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