Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism

Fulvestrant (Faslodex™) is a pure antiestrogen that is effective in treating estrogen receptor-(ER) positive breast cancer tumors that are resistant to selective estrogen receptor modulators such as tamoxifen. Clinical trials investigating the utility of adding fulvestrant to other therapeutics have...

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Bibliographic Details
Main Authors: Edavana, Vineetha K, Penney, Rosalind B, Yao-Borengasser, Aiwei, Williams, Suzanne, Rogers, Lora, Dhakal, Ishwori B, Kadlubar, Susan
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841332/
https://ncbi.nlm.nih.gov/pubmed/24298433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-2-620
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