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Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant

The Suppressor of Fused (SUFU) protein plays an essential role in the Hedgehog (HH) signaling pathway, by regulation of the GLI transcription factors. Two major isoforms of human SUFU are known, a full-length (SUFU-FL) and a carboxy-terminal truncated (SUFU- ΔC) variant. Even though SUFU- ΔC is expr...

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Detalhes bibliográficos
Main Authors: Tostar, Ulrica, Finta, Csaba, Rahman, Mohammed Ferdous-Ur, Shimokawa, Takashi, Zaphiropoulos, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362617/
https://ncbi.nlm.nih.gov/pubmed/22666390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037761
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