Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene

In irinotecan (CPT-11)-based chemotherapy, neutropenia and diarrhea are often induced. In the present study, the clinical significance of the concentration ratios of 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronide (SN-38G) and SN-38 in the plasma in predicting CPT-11-induced neutropenia was exami...

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Autori principali: HIROSE, KOICHI, KOZU, CHIHIRO, YAMASHITA, KOSHIRO, MARUO, EIJI, KITAMURA, MIZUHO, HASEGAWA, JUNICHI, OMODA, KEI, MURAKAMI, TERUO, MAEDA, YORINOBU
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362497/
https://ncbi.nlm.nih.gov/pubmed/22740978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2011.533
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