Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

Leukemic transformation (LT) of myeloproliferative neoplasms (MPNs) is associated with a poor prognosis and resistance to therapy. Although previous candidate genetic studies have identified mutations in MPN patients who develop acute leukemia, the complement of genetic abnormalities in MPN patients...

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Detalhes bibliográficos
Main Authors: Zhang, Su-Jiang, Rampal, Raajit, Manshouri, Taghi, Patel, Jay, Mensah, Nana, Kayserian, Andrew, Hricik, Todd, Heguy, Adriana, Hedvat, Cyrus, Gönen, Mithat, Kantarjian, Hagop, Levine, Ross L., Abdel-Wahab, Omar, Verstovsek, Srdan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362363/
https://ncbi.nlm.nih.gov/pubmed/22431577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-390252
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