Stimulation of Rho signaling by pathologic mechanical stretch is a “second hit” to Rho-independent lung injury induced by IL-6

Most patients with acute lung injury (ALI) and acute respiratory distress syndrome of septic and nonseptic nature require assisted ventilation with positive pressure, which at suboptimal range may further exacerbate lung dysfunction. Previous studies described enhancement of agonist-induced Rho GTPa...

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Bibliographic Details
Main Authors: Birukova, Anna A., Tian, Yufeng, Meliton, Angelo, Leff, Alan, Wu, Tinghuai, Birukov, Konstantin G.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362159/
https://ncbi.nlm.nih.gov/pubmed/22345573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00292.2011
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