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Rap-afadin axis in control of Rho signaling and endothelial barrier recovery

Activation of the Rho GTPase pathway determines endothelial cell (EC) hyperpermeability after injurious stimuli. To date, feedback mechanisms of Rho down-regulation critical for barrier restoration remain poorly understood. We tested a hypothesis that Rho down-regulation and barrier recovery of agon...

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Autors principals: Birukova, Anna A., Tian, Xinyong, Tian, Yufeng, Higginbotham, Katherine, Birukov, Konstantin G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756920/
https://ncbi.nlm.nih.gov/pubmed/23864716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-02-0098
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