Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1

Protective effects of prostacyclin (PC) or its stable analog beraprost against agonist-induced lung vascular inflammation have been associated with elevation of intracellular cAMP and Rac GTPase signaling which inhibited the RhoA GTPase-dependent pathway of endothelial barrier dysfunction. This stud...

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Publicat a:Biochim Biophys Acta
Autors principals: Birukova, Anna A., Meng, Fanyong, Tian, Yufeng, Meliton, Angelo, Sarich, Nicolene, Quilliam, Lawrence A., Birukov, Konstantin G.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372486/
https://ncbi.nlm.nih.gov/pubmed/25545047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.12.016
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