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Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine

Leucine (Leu) and insulin both stimulate muscle protein synthesis, albeit at least in part via separate signaling pathways. While alcohol (EtOH) suppresses insulin-stimulated protein synthesis in cultured myocytes, its ability to disrupt Leu signaling and Rag GTPase activity has not been determined....

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Bibliografiske detaljer
Main Authors: Hong-Brown, Ly Q., Brown, C. Randell, Kazi, Abid A., Navaratnarajah, Maithili, Lang, Charles H.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362004/
https://ncbi.nlm.nih.gov/pubmed/22442136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00407.2011
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