Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

Mammalian cells express dozens of iron-containing proteins, yet little is known about the mechanism of metal ligand incorporation. Human poly (rC) binding protein 1 (PCBP1) is an iron chaperone that binds iron and delivers it to ferritin, a cytosolic iron storage protein. We have identified the iron...

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Autores principales: Nandal, Anjali, Ruiz, Julio C., Subramanian, Poorna, Ghimire-Rijal, Sudipa, Sinnamon, Ruth Ann, Stemmler, Timothy L., Bruick, Richard K., Philpott, Caroline C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361910/
https://ncbi.nlm.nih.gov/pubmed/22055506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.08.015
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