Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

[Image: see text] The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug–drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in sili...

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Autors principals: Karlgren, Maria, Vildhede, Anna, Norinder, Ulf, Wisniewski, Jacek R., Kimoto, Emi, Lai, Yurong, Haglund, Ulf, Artursson, Per
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361267/
https://ncbi.nlm.nih.gov/pubmed/22541068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300212s
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