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Efficient correction of a mutation by use of chemically synthesized DNA.
The mutated base in the am3 lysis-defective mutant of the bacteriophage phiX174 has been corrected by a combined in vitro enzymatic DNA synthesis and in vivo replication of the heteroduplex product. Chemically synthesized oligodeoxyribonucleotides carrying the wild-type sequence have been used to pr...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1978
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336094/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/279913/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.9.4268 |
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