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Activation of β-Catenin by Oncogenic PIK3CA and EGFR Promotes Resistance to Glucose Deprivation by Inducing a Strong Antioxidant Response

Glucose is an essential fuel for cell survival and its availability limits aberrant cellular proliferation. We have hypothesized that specific cancer mutations regulate metabolic response(s) to glucose deprivation (GD). By means of somatic knock-in cellular models, we have analyzed the response to g...

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Autors principals: Cardone, Luca, Bardelli, Alberto, Avvedimento, Vittorio Enrico
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360841/
https://ncbi.nlm.nih.gov/pubmed/22662165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037526
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