Mathematical modeling mechanisms of arrhythmias in transgenic mouse heart overexpressing TNF-α

Transgenic mice overexpressing tumor necrosis factor-α (TNF-α mice) possess many of the features of human heart failure, such as dilated cardiomyopathy, impaired Ca(2+) handling, arrhythmias, and decreased survival. Although TNF-α mice have been studied extensively with a number of experimental meth...

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Autors principals: Petkova-Kirova, Polina S., London, Barry, Salama, Guy, Rasmusson, Randall L., Bondarenko, Vladimir E.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
Matèries:
Cardiac Excitation and Contraction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360583/
https://ncbi.nlm.nih.gov/pubmed/22081697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00493.2011
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