The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters

Oxidative stress has been implicated in the pathogenesis of many human diseases including Fanconi anemia (FA), a genetic disorder associated with BM failure and cancer. Here we show that major antioxidant defense genes are down-regulated in FA patients, and that gene down-regulation is selectively a...

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Detalhes bibliográficos
Main Authors: Du, Wei, Rani, Reena, Sipple, Jared, Schick, Jonathan, Myers, Kasiani C., Mehta, Parinda, Andreassen, Paul R., Davies, Stella M., Pang, Qishen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359736/
https://ncbi.nlm.nih.gov/pubmed/22408259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381970
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