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The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
Oxidative stress has been implicated in the pathogenesis of many human diseases including Fanconi anemia (FA), a genetic disorder associated with BM failure and cancer. Here we show that major antioxidant defense genes are down-regulated in FA patients, and that gene down-regulation is selectively a...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359736/ https://ncbi.nlm.nih.gov/pubmed/22408259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381970 |
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