A Humanized Pattern of Aromatase Expression Is Associated with Mammary Hyperplasia in Mice

Aromatase is essential for estrogen production and is the target of aromatase inhibitors, the most effective endocrine treatment for postmenopausal breast cancer. Peripheral tissues in women, including the breast, express aromatase via alternative promoters. Female mice lack the promoters that drive...

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Hlavní autoři: Zhao, Hong, Pearson, Elizabeth K., Brooks, David C., Coon V, John S., Chen, Dong, Demura, Masashi, Zhang, Ming, Clevenger, Charles V., Xu, Xia, Veenstra, Timothy D., Chatterton, Robert T., DeMayo, Francesco J., Bulun, Serdar E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2012
Témata:
General Endocrinology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359608/
https://ncbi.nlm.nih.gov/pubmed/22508516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1761
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