Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins

BACKGROUND: Cell migration is a highly regulated process that involves the formation and turnover of cell-matrix contact sites termed focal adhesions. Rho-family GTPases are molecular switches that regulate actin and focal adhesion dynamics in cells. Guanine nucleotide exchange factors (GEFs) activa...

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Bibliografiske detaljer
Main Authors: Miller, Nichol L. G., Lawson, Christine, Chen, Xiao Lei, Lim, Ssang-Taek, Schlaepfer, David D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359313/
https://ncbi.nlm.nih.gov/pubmed/22649559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037830
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