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Improvements in a Mouse Model of Alzheimer’s Disease Through SOD2 Overexpression are Due to Functional and Not Structural Alterations

Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of Alzheimer’s disease. We and others have shown that over expression of the mitochondrial antioxidant superoxide dismutase 2 (SOD-2) can improve many of the pathologies in the Tg2576 mouse model of Alzheimer’s d...

詳細記述

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書誌詳細
主要な著者: Bitner, Brittany R., Perez-Torres, Carlos J., Hu, Lingyun, Inoue, Taeko, Pautler, Robia G.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359050/
https://ncbi.nlm.nih.gov/pubmed/22639527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/MRI.S9352
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