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HMG–CoA Reductase Activation and Urinary Pellet Cholesterol Elevations in Acute Kidney Injury

SUMMARY: BACKGROUND AND OBJECTIVES: Experimental acute kidney injury (AKI) activates the HMG–CoA reductase (HMGCR) gene, producing proximal tubule cholesterol loading. AKI also causes sloughing of proximal tubular cell debris into tubular lumina. This study tested whether these two processes culmina...

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Hlavní autoři: Johnson, Ali CM, Ware, Lorraine B., Himmelfarb, Jonathan, Zager, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359009/
https://ncbi.nlm.nih.gov/pubmed/21799150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.02440311
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