Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse

Congenitally hypomyelinated shiverer mice fail to generate compact myelin, and die by 18–21 weeks of age. Using multifocal anterior and posterior fossa delivery of sorted fetal human glial progenitor cells into neonatal shiverer x rag2(−/−) immunodeficient and myelin-deficient mice, we achieved whol...

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Detalhes bibliográficos
Main Authors: Windrem, Martha, Schanz, Steve, Guo, Min, Tian, Guo-Feng, Washco, Vaughn, Stanwood, Nancy, Rasband, Matthew, Roy, Neeta S., Nedergaard, Maiken, Havton, Leif A., Wang, Su, Goldman, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358921/
https://ncbi.nlm.nih.gov/pubmed/18522848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.03.020
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