Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

Obesity triggers a low-grade systemic inflammation, which plays an important role in the development of obesity-associated metabolic diseases. In searching for links between lipid accumulation and chronic inflammation, we examined invariant natural killer T (iNKT) cells, a subset of T lymphocytes th...

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Autori principali: Wu, Lan, Parekh, Vrajesh V., Gabriel, Curtis L., Bracy, Deanna P., Marks-Shulman, Pamela A., Tamboli, Robyn A., Kim, Sungjune, Mendez-Fernandez, Yanice V., Besra, Gurdyal S., Lomenick, Jefferson P., Williams, Brandon, Wasserman, David H., Van Kaer, Luc
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358828/
https://ncbi.nlm.nih.gov/pubmed/22493234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200498109
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