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Exploring purine N7 interactions via atomic mutagenesis: The group I ribozyme as a case study

Atomic mutagenesis has emerged as a powerful tool to unravel specific interactions in complex RNA molecules. An early extensive study of analogs of the exogenous guanosine nucleophile in group I intron self-splicing by Bass and Cech demonstrated structure–function relationships analogous to those se...

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Main Authors: Forconi, Marcello, Benz-Moy, Tara, Gleitsman, Kristin Rule, Ruben, Eliza, Metz, Clyde, Herschlag, Daniel
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358644/
https://ncbi.nlm.nih.gov/pubmed/22543863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.031567.111
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