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Roles of Long-Range Tertiary Interactions in Limiting Dynamics of the Tetrahymena Group I Ribozyme

[Image: see text] We determined the effects of mutating the long-range tertiary contacts of the Tetrahymena group I ribozyme on the dynamics of its substrate helix (referred to as P1) and on catalytic activity. Dynamics were assayed by fluorescence anisotropy of the fluorescent base analogue, 6-meth...

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Bibliografiske detaljer
Main Authors: Shi, Xuesong, Bisaria, Namita, Benz-Moy, Tara L., Bonilla, Steve, Pavlichin, Dmitri S., Herschlag, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021564/
https://ncbi.nlm.nih.gov/pubmed/24738560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja413033d
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