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Structure-Function from the Outside In: Long-range Tertiary Contacts in RNA Exhibit Distinct Catalytic Roles
The conserved catalytic core of the Tetrahymena group I ribozyme is encircled by peripheral elements. We have carried out a detailed structure-function study of the five long-range tertiary contacts that fasten these distal elements together. Mutational ablation of each of the tertiary contacts dest...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3186870/ https://ncbi.nlm.nih.gov/pubmed/21815635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2008245 |
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