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PI3K-Independent AKT Activation in Cancers: A Treasure Trove for Novel Therapeutics
AKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and survival pathways, is frequently dysregulated in many cancers. Although phosphatidylinositol-3-OH kinase (PI3K), a lipid kinase, is well characterized as a major regulator of AKT activation in response to a vari...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358464/ https://ncbi.nlm.nih.gov/pubmed/22307544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24065 |
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