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Improving the Stability of the EC1 Domain of E-cadherin by Thiol Alkylation of the Cysteine Residue
The objective of this work was to improve chemical and physical stability of the EC1 protein derived from the extracellular domain of E-cadherin. In solution, the EC1 protein has been shown to form a covalent dimer via a disulfide bond formation followed by physical aggregation and precipitation. To...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358404/ https://ncbi.nlm.nih.gov/pubmed/22531851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2012.03.051 |
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