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Evaluation of the Physical Stability of the EC5 Domain of E-Cadherin: Effects of pH, Temperature, Ionic strength, and Disulfide Bonds

The development of protein drugs has been hampered by difficulties in formulating them due to their inherent chemical and physical stability, which could generate problems during the late stages of development. Thus, a basic understanding of the effect of structural features on the physicochemical s...

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Detalhes bibliográficos
Principais autores: ZHENG, KAI, MIDDAUGH, C. RUSSELL, SIAHAAN, TERUNA J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311108/
https://ncbi.nlm.nih.gov/pubmed/18428798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21418
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