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Evaluation of the Physical Stability of the EC5 Domain of E-Cadherin: Effects of pH, Temperature, Ionic strength, and Disulfide Bonds
The development of protein drugs has been hampered by difficulties in formulating them due to their inherent chemical and physical stability, which could generate problems during the late stages of development. Thus, a basic understanding of the effect of structural features on the physicochemical s...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311108/ https://ncbi.nlm.nih.gov/pubmed/18428798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21418 |
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