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Improving the Stability of the EC1 Domain of E-cadherin by Thiol Alkylation of the Cysteine Residue

The objective of this work was to improve chemical and physical stability of the EC1 protein derived from the extracellular domain of E-cadherin. In solution, the EC1 protein has been shown to form a covalent dimer via a disulfide bond formation followed by physical aggregation and precipitation. To...

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Bibliografiske detaljer
Main Authors: Trivedi, Maulik, Laurence, Jennifer S., Williams, Todd D., Middaugh, C. Russell, Siahaan, Teruna J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358404/
https://ncbi.nlm.nih.gov/pubmed/22531851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2012.03.051
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