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The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin

The objective of this work was to evaluate the solution stability of the EC1 domain of E-cadherin under various conditions. The EC1 domain was incubated at various temperatures (4, 37, and 70 °C) and pH values (3.0, 7.0, and 9.0). At pH 9.0 and 37 or 70 °C, a significant loss of EC1 was observed due...

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Detalhes bibliográficos
Main Authors: Trivedi, Maulik, Davis, R. Andrew, Shabaik, Yumna, Roy, Ambrish, Verkhivker, Gennady, Laurence, Jennifer, Middaugh, C. Russell, Siahaan, Teruna J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319692/
https://ncbi.nlm.nih.gov/pubmed/19199298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21686
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