Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

Diseases that cause hemolysis or myonecrosis lead to the leakage of large amounts of heme proteins. Free heme has proinflammatory and cytotoxic effects. Heme induces TLR4-dependent production of tumor necrosis factor (TNF), whereas heme cytotoxicity has been attributed to its ability to intercalate...

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Detalhes bibliográficos
Main Authors: Fortes, Guilherme B., Alves, Leticia S., de Oliveira, Rosane, Dutra, Fabianno F., Rodrigues, Danielle, Fernandez, Patricia L., Souto-Padron, Thais, De Rosa, María José, Kelliher, Michelle, Golenbock, Douglas, Chan, Francis K. M., Bozza, Marcelo T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358230/
https://ncbi.nlm.nih.gov/pubmed/22262768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-375303
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