Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

Diseases that cause hemolysis or myonecrosis lead to the leakage of large amounts of heme proteins. Free heme has proinflammatory and cytotoxic effects. Heme induces TLR4-dependent production of tumor necrosis factor (TNF), whereas heme cytotoxicity has been attributed to its ability to intercalate...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Fortes, Guilherme B., Alves, Leticia S., de Oliveira, Rosane, Dutra, Fabianno F., Rodrigues, Danielle, Fernandez, Patricia L., Souto-Padron, Thais, De Rosa, María José, Kelliher, Michelle, Golenbock, Douglas, Chan, Francis K. M., Bozza, Marcelo T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2012
Gaiak:
Phagocytes, Granulocytes, and Myelopoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358230/
https://ncbi.nlm.nih.gov/pubmed/22262768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-375303
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