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Hemolysis-induced lethality involves inflammasome activation by heme
The increase of extracellular heme is a hallmark of hemolysis or extensive cell damage. Heme has prooxidant, cytotoxic, and inflammatory effects, playing a central role in the pathogenesis of malaria, sepsis, and sickle cell disease. However, the mechanisms by which heme is sensed by innate immune c...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4191786/ https://ncbi.nlm.nih.gov/pubmed/25225402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405023111 |
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