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Hemolysis-induced lethality involves inflammasome activation by heme

The increase of extracellular heme is a hallmark of hemolysis or extensive cell damage. Heme has prooxidant, cytotoxic, and inflammatory effects, playing a central role in the pathogenesis of malaria, sepsis, and sickle cell disease. However, the mechanisms by which heme is sensed by innate immune c...

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Detalhes bibliográficos
Main Authors: Dutra, Fabianno F., Alves, Letícia S., Rodrigues, Danielle, Fernandez, Patricia L., de Oliveira, Rosane B., Golenbock, Douglas T., Zamboni, Dario S., Bozza, Marcelo T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191786/
https://ncbi.nlm.nih.gov/pubmed/25225402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405023111
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