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Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway
Heme is an essential cofactor for numerous cellular functions, but release of free heme during hemolysis results in oxidative tissue damage, vascular dysfunction, and inflammation. Macrophages play a key protective role in heme clearance; however, the mechanisms that regulate metabolic adaptations t...
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| Publicat a: | Blood |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7515686/ https://ncbi.nlm.nih.gov/pubmed/32556090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020004964 |
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