Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

OBJECTIVE: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains enigmatic. METHODS: Here we identify the critical r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Metab
Prif Awduron: Serbulea, Vlad, Upchurch, Clint M., Ahern, Katelyn W., Bories, Gael, Voigt, Paxton, DeWeese, Dory E., Meher, Akshaya K., Harris, Thurl E., Leitinger, Norbert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2017
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784323/
https://ncbi.nlm.nih.gov/pubmed/29153923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.11.002
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