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Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

OBJECTIVE: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains enigmatic. METHODS: Here we identify the critical r...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Metab
Κύριοι συγγραφείς: Serbulea, Vlad, Upchurch, Clint M., Ahern, Katelyn W., Bories, Gael, Voigt, Paxton, DeWeese, Dory E., Meher, Akshaya K., Harris, Thurl E., Leitinger, Norbert
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784323/
https://ncbi.nlm.nih.gov/pubmed/29153923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.11.002
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