Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

OBJECTIVE: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains enigmatic. METHODS: Here we identify the critical r...

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Veröffentlicht in:Mol Metab
Hauptverfasser: Serbulea, Vlad, Upchurch, Clint M., Ahern, Katelyn W., Bories, Gael, Voigt, Paxton, DeWeese, Dory E., Meher, Akshaya K., Harris, Thurl E., Leitinger, Norbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784323/
https://ncbi.nlm.nih.gov/pubmed/29153923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.11.002
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