Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3,...

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Autors principals: Michaelis, M, Rothweiler, F, Agha, B, Barth, S, Voges, Y, Löschmann, N, von Deimling, A, Breitling, R, Wilhelm Doerr, H, Rödel, F, Speidel, D, Cinatl, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358013/
https://ncbi.nlm.nih.gov/pubmed/22476102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.35
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