Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3,...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Michaelis, M, Rothweiler, F, Agha, B, Barth, S, Voges, Y, Löschmann, N, von Deimling, A, Breitling, R, Wilhelm Doerr, H, Rödel, F, Speidel, D, Cinatl, J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358013/
https://ncbi.nlm.nih.gov/pubmed/22476102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.35
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items