Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells

Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyosarcoma, and melanoma) were continuously exposed to increasing concentrations of the murine double minute 2 inhibitor nutlin-3, resulting in the emergence of nutlin-3-resistant, p53-mutated sublines d...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Michaelis, M, Rothweiler, F, Barth, S, Cinatl, J, van Rikxoort, M, Löschmann, N, Voges, Y, Breitling, R, von Deimling, A, Rödel, F, Weber, K, Fehse, B, Mack, E, Stiewe, T, Doerr, H W, Speidel, D
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252738/
https://ncbi.nlm.nih.gov/pubmed/22170099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.129
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker