ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance

The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major determinant of SNS-032 resistance. Here, we investigated the role of ABCB1 in acquired SNS-032 resistance. In contrast to ABCB1-expressing UKF-NB...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Löschmann, Nadine, Michaelis, Martin, Rothweiler, Florian, Voges, Yvonne, Balónová, Barbora, Blight, Barry A., Cinatl, Jindrich
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295411/
https://ncbi.nlm.nih.gov/pubmed/27517323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11160
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