Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance

Resistance formation after initial therapy response (acquired resistance) is common in high-risk neuroblastoma patients. YM155 is a drug candidate that was introduced as a survivin suppressant. This mechanism was later challenged, and DNA damage induction and Mcl-1 depletion were suggested instead....

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Voges, Yvonne, Michaelis, Martin, Rothweiler, Florian, Schaller, Torsten, Schneider, Constanze, Politt, Katharina, Mernberger, Marco, Nist, Andrea, Stiewe, Thorsten, Wass, Mark N, Rödel, Franz, Cinatl, Jindrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133961/
https://ncbi.nlm.nih.gov/pubmed/27735941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.257
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