Nucleotide sequence, DNA damage location and protein stoichiometry influence base excision repair outcome at CAG/CTG repeats

Expansion of CAG/CTG repeats is the underlying cause of >fourteen genetic disorders, including Huntington’s disease (HD) and myotonic dystrophy. The mutational process is ongoing, with increases in repeat size enhancing the toxicity of the expansion in specific tissues. In many repeat diseases th...

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Bibliographic Details
Main Authors: Goula, Agathi-Vasiliki, Pearson, Christopher E., Della Maria, Julie, Trottier, Yvon, Tomkinson, Alan E., Wilson, David M., Merienne, Karine
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357312/
https://ncbi.nlm.nih.gov/pubmed/22497302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300410d
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