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Tissue-dependent regulation of RNAP II dynamics: The missing link between transcription and trinucleotide repeat instability in diseases?
More than 15 human genetic diseases, including Huntington’s disease, result from the expansion of a trinucleotide repeat. The expansions are unstable in specific somatic tissues, which can lead to disease acceleration. Here we discuss the role of transcription elongation in tissue-selective trinucle...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977917/ https://ncbi.nlm.nih.gov/pubmed/23989661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.25971 |
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