Class II Histone Deacetylases Downregulate GLUT4 Transcription in Response to Increased cAMP Signaling in Cultured Adipocytes and Fasting Mice

Insulin-mediated glucose uptake is highly sensitive to the levels of the facilitative glucose transporter protein, GLUT4. Repression of GLUT4 expression is correlated with insulin resistance in adipose tissue. We have shown that differentiation-dependent GLUT4 transcription was under control of clas...

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Hlavní autoři: Weems, Juston C., Griesel, Beth A., Olson, Ann Louise
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357296/
https://ncbi.nlm.nih.gov/pubmed/22403301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0737
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