Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and K(ATP) Channel Inhibition

Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of our study was to test whether pancreatic β-cells contribute to BA-dependent regulation of glucose homeostasis. Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (K...

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Autores principales: Düfer, Martina, Hörth, Katrin, Wagner, Rebecca, Schittenhelm, Björn, Prowald, Susanne, Wagner, Thomas F.J., Oberwinkler, Johannes, Lukowski, Robert, Gonzalez, Frank J., Krippeit-Drews, Peter, Drews, Gisela
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357280/
https://ncbi.nlm.nih.gov/pubmed/22492528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0815
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