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The expanding relevance of nuclear mTOR in carcinogenesis

Deregulated mTOR signaling drives the growth of various human cancers, making mTOR a major target for development of cancer chemotherapeutics. The role of mTOR in carcinogenesis is thought to be largely a consequence of its activity in the cytoplasm, resulting in increased translation of pro-tumorig...

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Bibliographic Details
Main Authors: Back, Jung H, Kim, Arianna L
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356804/
https://ncbi.nlm.nih.gov/pubmed/22067472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.22.18329
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