Varenicline Blocks β2*-nAChR–Mediated Response and Activates β4*-nAChR–Mediated Responses in Mice In Vivo

INTRODUCTION: The smoking cessation aid, varenicline, has higher affinity for the alpha4beta2-subtype of the nicotinic acetylcholine receptor (α4β2*-nAChR) than for other subtypes of nAChRs by in vitro assays. The mechanism of action of acute varenicline was studied in vivo to determine (a) subtype...

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Main Authors: Ortiz, Nick C., O’Neill, Heidi C., Marks, Michael J., Grady, Sharon R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2012
Ábhair:
Original Investigations
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356295/
https://ncbi.nlm.nih.gov/pubmed/22241831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ntr/ntr284
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